Conformational conversion of prion protein in prion diseases
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چکیده
منابع مشابه
Conformational conversion of prion protein in prion diseases.
Prion diseases are a group of infectious fatal neurodegenerative diseases. The conformational conversion of a cellular prion protein (PrP(C)) into an abnormal misfolded isoform (PrP(Sc)) is the key event in prion diseases pathology. Under normal conditions, the high-energy barrier separates PrP(C) from PrP(Sc) isoform. However, pathogenic mutations, modifications as well as some cofactors, such...
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Prion diseases, or transmissible spongiform encephalopathies (TSEs) are progressive, fatal neurodegenerative diseases with no effective treatment. The pathology of these diseases involves the conversion of a protease sensitive form of the cellular prion protein (PrP(C)) into a protease resistant infectious form (PrP(res)). The efficiency of this conversion is predicated upon a number of factors...
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2013
ISSN: 1672-9145,1745-7270
DOI: 10.1093/abbs/gmt027